Zulresso  (brexanolone) –  To treat postpartum depression (PPD) in adult women.

Box and Vial of Zulresso

 

ZULRESSO DOSAGE AND ADMINISTRATION 

• A healthcare provider must be available on site recommended reading to continuously monitor the patient, and intervene as necessary, for the duration of the infusion.
• Administered as a continuous intravenous infusion over 60 hours (2.5 days) as follows :

  • 0 to 4 hours: Initiate with a dosage of 30 mcg/kg/hour
  • 4 to 24 hours: Increase dosage to 60 mcg/kg/hour
  •  24 to 52 hours: Increase dosage to 90 mcg/kg/hour (alternatively consider a dosage of 60 mcg/kg/hour for those who do not tolerate
    90 mcg/kg/hour)
  • 52 to 56 hours: Decrease dosage to 60 mcg/kg/hour
  • 56 to 60 hours: Decrease dosage to 30 mcg/kg/hour

• Dilution required prior to administration.

 

ZULRESSO INDICATIONS AND USAGE

ZULRESSO is a neuroactive steroid gamma-aminobutyric acid (GABA) A receptor positive modulator indicated for the treatment of postpartum
depression (PPD) in adults.

 

ZULRESSO ADVERSE REACTIONS 

Most common adverse reactions (incidence ≥5% and at least twice the rate of placebo) were sedation/somnolence, dry mouth, loss of consciousness, and flushing/hot flush.

 

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